The Physical Science Building at SUNY Oneonta has undergone a major renovation / addition which was completed in the summer of 2017. Existing building constraints, such as the 12-foot floor-to- floor height required creative infrastructure design solutions. Ellenzweig / BR+A’s design included Aircuity’s real-time assessment of air quality allowing for overall lower air change rates consistent with ASHRAE’s Laboratory Guidelines (2015) for “demand-based control” and SUCF’s laboratory directives for “active sensing”. Aircuity and other efficient design solutions (e.g. chilled beams) enabled a reduction in primary equipment, a shallow ductwork distribution network and other features to meet these design challenges. Post-occupancy feedback confirms an energy use intensity of 90 kBtu/sf/year—a 10 percent improvement over predicted energy usage, rendering the building 67 percent carbon neutral relative to the US average of this building type.This is the 7th SUNY building project for Green Building Partners and Aircuity and 10 th SUNY building project for SUNY (with Aircuity).